{"id":1116,"date":"2020-07-11T14:49:19","date_gmt":"2020-07-11T12:49:19","guid":{"rendered":"https:\/\/covid.si\/?p=1116"},"modified":"2020-11-02T21:07:59","modified_gmt":"2020-11-02T20:07:59","slug":"misija-6-inhibitorji-furina","status":"publish","type":"post","link":"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/","title":{"rendered":"MI6: Zavrimo COVID-19 z inhibitorji furina"},"content":{"rendered":"\t\t
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MI6: Zavrimo COVID-19 z inhibitorji furina<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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STATUS MISIJE:\u00a0REZULTATI V OBDELAVI<\/strong><\/h5>
\u00a0<\/strong><\/div>
NA\u010cRT MISIJE:\u00a0 dr. \u010crtomir Podlipnik\u00a0<\/strong><\/h5>
\u0160tevilo tar\u010d: 2<\/h5>
Oznake tar\u010d: 49-50<\/strong><\/h5>
\u0160tevilo spojin: preko\u00a010 M<\/strong><\/h5>
Skupaj sidrano 20 M<\/b>\u00a0spojin<\/h5>
Trajanje misije: 01.07.2020 –<\/strong><\/h5>
Rezultati: v obdelavi<\/strong><\/h5>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/p>

\u00a0<\/p>

Slika prikazuje aminokisline na mestih cepitve v S glikoproteinih razli\u010dnih CoV. Glikoproteini virusov HCoV-OC43, HCoV-HKU1,
MERS-CoV in SARS-CoV 2 vsebujejo mesto – bogato z arginini, ki je podv\u017eeno <\/span>cepitvi s furinom. Mesto je bogato ve\u010d osnovnih <\/span>
(argininskih) aminokislin. S glikoproteini virusov HCoV-NL63, <\/span>
HCoV-229E in SARS-CoV ne omenjenega mesta cepitve.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Seznam tar\u010d:<\/strong>
#49<\/strong> 5jxh<\/a> Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution.<\/p>

#50<\/strong>\u00a05mim<\/a>\u00a0Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n<\/p>

OPIS MISIJE:<\/u><\/p>

REFERENCE:<\/p>

https:\/\/en.wikipedia.org\/wiki\/Furin<\/a><\/p>

https:\/\/www.nature.com\/articles\/s41392-020-0184-0<\/a><\/p>

https:\/\/www.virology.ws\/2020\/05\/14\/sars-cov-2-furin-cleavage-site-revisited\/<\/a><\/p>

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7114094\/<\/a>\u00a0<\/p>

\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

STATUS MISIJE: REZULTATI V OBDELAVI   NA\u010cRT MISIJE:  dr. \u010crtomir Podlipnik  \u0160tevilo tar\u010d: 2 Oznake tar\u010d: 49-50 \u0160tevilo spojin: preko 10 M […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[39,4,38,41,40,37],"yoast_head":"\nMI6: Zavrimo COVID-19 z inhibitorji furina - COVID.SI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MI6: Zavrimo COVID-19 z inhibitorji furina - COVID.SI\" \/>\n<meta property=\"og:description\" content=\"STATUS MISIJE: REZULTATI V OBDELAVI   NA\u010cRT MISIJE:  dr. \u010crtomir Podlipnik  \u0160tevilo tar\u010d: 2 Oznake tar\u010d: 49-50 \u0160tevilo spojin: preko 10 M […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/\" \/>\n<meta property=\"og:site_name\" content=\"COVID.SI\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-11T12:49:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-02T20:07:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/covid.si\/wp-content\/uploads\/2020\/07\/furin-300x92.png\" \/>\n<meta name=\"author\" content=\"dr. \u010crtomir Podlipnik\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"dr. \u010crtomir Podlipnik\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/\"},\"author\":{\"name\":\"dr. \u010crtomir Podlipnik\",\"@id\":\"https:\/\/covid.si\/#\/schema\/person\/822db59cdde4285ebde7b9e13a67c320\"},\"headline\":\"MI6: Zavrimo COVID-19 z inhibitorji furina\",\"datePublished\":\"2020-07-11T12:49:19+00:00\",\"dateModified\":\"2020-11-02T20:07:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/\"},\"wordCount\":159,\"publisher\":{\"@id\":\"https:\/\/covid.si\/#organization\"},\"image\":{\"@id\":\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/covid.si\/wp-content\/uploads\/2020\/07\/furin-300x92.png\",\"keywords\":[\"cepitev S proteina s furinom\",\"COvid-19\",\"Furin\",\"na\u010drtovanje zdravil\",\"patogeneza SARS-CoV-2\",\"S protein\"],\"articleSection\":[\"Missions of the Project\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/\",\"url\":\"https:\/\/covid.si\/en\/misija-6-inhibitorji-furina\/\",\"name\":\"MI6: Zavrimo COVID-19 z inhibitorji furina - 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