{"id":311,"date":"2020-04-11T01:21:39","date_gmt":"2020-04-10T23:21:39","guid":{"rendered":"https:\/\/covid.si\/?p=311"},"modified":"2020-04-11T01:34:06","modified_gmt":"2020-04-10T23:34:06","slug":"about-ncov-sars-2","status":"publish","type":"post","link":"https:\/\/covid.si\/en\/about-ncov-sars-2\/","title":{"rendered":"About NCOV-SARS-2"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"311\" class=\"elementor elementor-311\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-bca1273 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bca1273\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b505e4c\" data-id=\"b505e4c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4bbee6b elementor-widget elementor-widget-text-editor\" data-id=\"4bbee6b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Let us start this post about the virus currently threatening us with a quote from famous military strategist Sun Tzu:<\/p><p><i>&#8220;If you know the enemy and know yourself, you need not fear the result of a hundred battles.&#8221;\u00a0<\/i><\/p><p>Humanity is currently facing an enormous trial in the combined fight against our common &#8220;invisible&#8221; enemy &#8211; the SARS-CoV-2 virus. The wisdom above tells us, that knowing your enemy, in our case &#8211; the virus, is key in making a successful and efficient battle.<\/p><p>Our &#8220;invisible&#8221; enemy is the SARS-CoV-2 virus, also known as novel coronavirus, and is a positive sense single-strand RNA virus from the family <i>Coronaviridiae. <\/i>An infection with said virus often causes severe acute respiratory syndrome, which puts patients in mortal danger, especially elderly patients with preexisting chronic medical conditions. The virus is very contagious and the cause of the COVID-19 pandemic.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-78ef076 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"78ef076\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-92a76f4\" data-id=\"92a76f4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-697daf0 elementor-widget elementor-widget-text-editor\" data-id=\"697daf0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h6><strong>A short but informative video on SARS-CoV-2<\/strong><\/h6>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-ec2b3c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ec2b3c4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2fb6eb0\" data-id=\"2fb6eb0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf2694f elementor-widget elementor-widget-html\" data-id=\"bf2694f\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<iframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/BtN-goy9VOY\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-dc62bf0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dc62bf0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f23470d\" data-id=\"f23470d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-955bf37 elementor-widget elementor-widget-text-editor\" data-id=\"955bf37\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h6>SARS-NCOV-2 lifecycle<\/h6>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-3a5bdd8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a5bdd8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1352b48\" data-id=\"1352b48\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-03f2c45 elementor-widget elementor-widget-text-editor\" data-id=\"03f2c45\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>SARS-CoV-2 enters its host cells endosomatically. (0) First, the viral <b>S protein <\/b>attaches i to the <b>ACE2 receptor<\/b>\u00a0(Angiotenzin Converting Enzyme 2). This is followed by endocytosis, which is how the virus enters the host cell. (1) The virus is first contained in an endosome, which is a tubular membrane structure or follicle inside the cell, which forms from the cellular membrane and is part of intracellular transport. In the next stage, the viral and endosomal membrane fuse, which then leads to the\u00a0 the decomposition of the endosome. The viral genetic material (+)-RNA is released into the cell. (3) The cell&#8217;s ribosomes then read the viral RNA and build polypeptide chains from the &#8220;recipe.&#8221; (4) Viral protease (<b>3CLPro<\/b>) then splits the polypeptide chains into smaller proteins. (5) Several non-structural proteins then combine to form replication\/transcription complexes (<b>RTK<\/b>). The most important protein in said complex is RNA dependent RNP polymerase (<b>RdRp<\/b>), which directly participates in RNA duplication and transcription. The aforementioned complex makes subgenomic (+)RNA fragments, and pregenomic (-)RNA. (5) Pregenomic (-)RNA is responcible for replication, during which genomic (+)RNA is formed. (6) Subgenomic (+)RNA fragments are responsible for forming new copies of viral proteins. (7) Next comes the formation and (8) release of the virus.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-9af32b7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9af32b7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f743d58\" data-id=\"f743d58\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-109652f elementor-widget elementor-widget-image\" data-id=\"109652f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1176\" height=\"643\" src=\"https:\/\/covid.si\/wp-content\/uploads\/2020\/04\/The_life_cycle_of_SARS-CoV-slo.svg\" class=\"attachment-1536x1536 size-1536x1536 wp-image-305\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-cc450b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cc450b3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-505dbf1\" data-id=\"505dbf1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bfd573 elementor-widget elementor-widget-text-editor\" data-id=\"8bfd573\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>FORMING A STRATEGY BASED ON THE LIFE CYCLE OF THE VIRUS<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-34d8300 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34d8300\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b109999\" data-id=\"b109999\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6366a7c elementor-widget elementor-widget-text-editor\" data-id=\"6366a7c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>To be continued &#8230;.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Let us start this post about the virus currently threatening us with a quote from famous military strategist Sun Tzu: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - 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