Misija 4: Iskanje inhibitorjev encima DHODH

STATUS MISIJE: REZULTATI V OBDELAVI
 
NAČRT MISIJE: Domen Oblak in dr. Črtomir Podlipnik
Število tarč: 6
Oznake tarč: 35-40
Število spojin: preko 10 M
Skupaj sidrano 60 M spojin
Trajanje misije: 27.05.2020 –
Rezultati: v obdelavi

Seznam tarč:

#35 4ighHigh resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

#36 4jtuCrystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue

#37 4oqvHigh resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)

#38 3i65Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1

#39 4cq8Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178

#40 4rx0Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265

OPIS MISIJE: 

REFERENCE:

Xiong R, Zhang L, Li S, et al. Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2. bioRxiv; 2020. DOI: 10.1101/2020.03.11.983056.