MI 4: Zavrimo COVID-19 – Zaviralci DHODH

Seznam tarč:

#35 4igh – High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

#36 4jtu – Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue

#37 4oqv – High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)

#38 3i65 – Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1

#39 4cq8 – Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178

#40 4rx0 – Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265

OPIS MISIJE: 

REFERENCE:

Xiong R, Zhang L, Li S, et al. Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2. bioRxiv; 2020. DOI: 10.1101/2020.03.11.983056.