MISIJA 5 – Inhibitorji virusne proteaze PLPro (SARS-CoV, SARS-CoV2)

STATUS MISIJE: REZULTATI V OBDELAVI
 
NAČRT MISIJE:  dr. Črtomir Podlipnik in Gašper Tomšič
Število tarč: 8
Oznake tarč: 41-48
Število spojin: preko 10 M
Skupaj sidrano 80 M spojin
Trajanje misije: 16.06.2020 –
Rezultati: v obdelavi

Seznam tarč:

#41 2fe8SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme

#42 3mp2 – Crystal structure of transmissible gastroenteritis virus papain-like protease 1

#43 4ow0X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases

#44 6w9cThe crystal structure of papain-like protease of SARS CoV-2

#45 6wrh The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant

#46 6wuuCrystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR250

#47 6wx4Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR251

#48 6wzuThe crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group

 

OPIS MISIJE: 

REFERENCE:

https://doi.org/10.1016/j.antiviral.2014.12.015

https://www.drugtargetreview.com/news/63123/naphthalene-based-plpro-inhibitors-show-potential-as-covid-19-therapeutics/

https://doi.org/10.1101/2020.02.23.20026690